NMN and the Brain: Unlocking Potential Benefits

更新日: 2023年12月5日

In recent years, the spotlight has shifted towards an intriguing compound in the world of health and wellness: NMN (Nicotinamide Mononucleotide).

Touted for its potential to enhance brain health, NMN has caught the attention of researchers and health enthusiasts alike. As we age, our cognitive functions often decline, leading many to seek ways to maintain their mental sharpness. This is where NMN steps in, promising to bolster brain health through its unique biochemical properties.

In this article, we'll explore the science behind NMN, its potential benefits for the brain, and what current research says about this compelling supplement.

The Science Behind NMN and Brain Health

Understanding NAD+ and Its Role in the Brain

Nicotinamide Adenine Dinucleotide (NAD+) plays a pivotal role in brain health. Found in every cell, NAD+ is essential for energy production and cellular function. However, as we age, NAD+ levels naturally decline, leading to mitochondrial dysfunction and, consequently, cognitive decline. Environmental stressors like pollution and radiation further exacerbate this reduction.

This is where NMN steps into the picture. As a precursor to NAD+, NMN supplementation could potentially replenish these declining levels, thereby supporting brain health and function. [1] By maintaining optimal NAD+ levels, NMN could be crucial in sustaining the brain's energy metabolism and overall health, especially as we grow older.

NMN's Potential in Replenishing NAD+

Supplementing with NMN has shown promising results in boosting NAD+ levels, particularly in the brain.

Research in animal models has demonstrated that NMN supplementation can lead to notable improvements in cognitive functions. [2] Studies on aged mice have revealed enhanced spatial working memory, better gait coordination, and improved neurovascular health following NMN supplementation. These benefits are primarily attributed to the replenishment of NAD+ stores in the brain, which is essential for maintaining healthy brain function.

These findings suggest that NMN could play a significant role in improving cognitive abilities, especially in the context of aging, where NAD+ levels naturally diminish.

NMN and Neurodegenerative Diseases

The potential of NMN in combating neurodegenerative diseases like Alzheimer's is an area of growing interest.

NMN's ability to repair cellular damage in the brain and inhibit the buildup of beta-amyloid plaques offers hope in the fight against these debilitating conditions. Beta-amyloid plaques are commonly associated with Alzheimer's and other neurodegenerative diseases, and their buildup leads to cognitive decline.

By preventing these plaques, NMN could be a key player in protecting brain health and function. While research in this area is still in the early stages, the initial findings are promising and point towards NMN's potential role in neuroprotection. [3​​][4​​][5]​​[6]​.

Enhancing Neurovascular Health

Beyond its direct effects on brain cells, NMN also benefits the neurovascular system, which is critical for delivering nutrients and oxygen to the brain[7]​.

As we age, this system's efficiency declines, leading to reduced cognitive abilities.

NMN has been found to rejuvenate this system in aged mice, indicating its potential in improving overall brain health and function​[8​]. By enhancing the health and integrity of the neurovascular system, NMN could play a crucial role in maintaining cognitive function, particularly in older individuals​[9]​.

This aspect of NMN's action underscores its multifaceted approach to promoting brain health​[10]​.

The decline in cognitive function is a common concern associated with aging. NMN's role in mitigating this decline is particularly noteworthy. [11] By boosting NAD+ levels, NMN supplements can support the regeneration of cells, thus slowing down the aging process at a cellular level. This regeneration is crucial for maintaining brain health and cognitive function. With aging, the natural decrease in NAD+ and sirtuins disrupts this regeneration, leading to rapid aging and cognitive decline. NMN supplementation, therefore, holds promise in not only enhancing brain health but also in potentially reversing some aspects of cognitive decline associated with aging.

Methods of NMN Supplementation

NMN supplements come in various forms, with intranasal NMN emerging as an effective method to deliver NMN directly to the brain. This form of administration bypasses the blood-brain barrier, allowing for lower doses and reduced side effects.

Intranasal NMN has shown excellent increases in NMN levels in the brain, making it a potentially more effective option for cognitive health. Most commonly available in nasal spray bottles, intranasal NMN offers a practical and efficient way to harness the benefits of NMN for brain health.

Potential Risks and Considerations

While NMN supplements show promise for brain health, it's important to approach them with caution.

Most of the research, particularly those showing significant benefits, has been conducted on animal models. [11 Human studies are still in their infancy, and there is no definitive proof yet of NMN's efficacy in improving brain health in humans.

Additionally, the long-term effects and safety profile of NMN supplementation are not fully understood. As with any supplement, potential interactions with other medications and health conditions should be considered.

Therefore, it is crucial for individuals to consult healthcare professionals before starting NMN supplementation, and to stay updated with ongoing research in this field.


1. What is NMN and how does it support brain health?

NMN is a precursor to NAD+, essential for energy production and cellular function in the brain. It may help replenish declining NAD+ levels, potentially improving cognitive functions and neurovascular health.

2. Can NMN supplements prevent neurodegenerative diseases?

Early research indicates NMN's potential in inhibiting beta-amyloid plaques associated with diseases like Alzheimer's, but more conclusive human studies are needed.

3. Is intranasal NMN more effective than other forms?

Intranasal NMN can bypass the blood-brain barrier, potentially leading to increased NMN levels in the brain with fewer side effects. It's a promising method, but individual efficacy may vary.


NMN supplements show potential in enhancing brain health, especially for combating age-related cognitive decline. Key aspects include:

  • NAD+ and Brain Health: Essential for energy production, NMN may boost declining NAD+ levels in the brain.
  • Cognitive Function Improvement: Animal studies indicate NMN's potential in enhancing cognitive abilities and neurovascular health.
  • Potential in Neurodegenerative Diseases: NMN could play a role in repairing brain cellular damage and inhibiting beta-amyloid plaque buildup.
  • Neurovascular System Support: NMN might improve the neurovascular system, crucial for cognitive function.
  • Intranasal NMN Efficacy: This method could effectively deliver NMN to the brain.

While promising, this research is mostly in early stages and based on animal studies. The effectiveness and safety in humans require further investigation. Consulting healthcare professionals is recommended for anyone considering NMN supplements. NMN continues to be a hopeful avenue for maintaining cognitive health amid aging.